133 research outputs found
New Photosensitizers Based on Heteroleptic Cu Complexes and CO Photocatalytic Reduction with [Ni(cyclam)]Cl
Earthâabundant metal complexes have been attracting increasing attention in the field of photo(redox)catalysis. In this work, the synthesis and full characterisation of four new heteroleptic Cu complexes are reported, which can work as photosensitizers. The complexes bear a bulky diphosphine (DPEPhos=bis[(2âdiphenylphosphino)phenyl] ether) and a diimine chelating ligand based on 1âbenzylâ4â(quinolâ2âČyl)â1,2,3âtriazole. Their absorption has a relative maximum in the visibleâlight region, up to 450â
nm. Thus, their use in photocatalytic systems for the reduction of CO with blue light in combination with the known catalyst [Ni(cyclam)]Cl was tested. This system produced CO as the main product through visible light (λ =420â
nm) with a TON up to 8 after 4â
hours. This value is in line with other photocatalytic systems using the same catalyst. Nevertheless, this system is entirely nobleâmetal free
Correction: Phosphorescent bio-based resin for digital light processing (DLP) 3D-printing
Correction for 'Phosphorescent bio-based resin for digital light processing (DLP) 3D-printing' by Mirko Maturi et al., Green Chem., 2020, 22, 6212â6224, DOI: 10.1039/D0GC01983F
Itaconic-Acid-Based Sustainable Poly(ester amide) Resin for Stereolithography
Material science is recognized as a frontrunner in achieving a sustainable future, owing to its primary reliance upon petroleum-based chemical raw materials. Several efforts are made to implement common renewable feedstocks as an alternative to common fossil resources. For this purpose, additive manufacturing (AM) represents promising and effective know-how for the replacement of high energy- and resource-demanding processes with more environmentally friendly practices. This work presents a novel biobased ink for stereolithography, which has been formulated by mixing a photocurable poly(ester amide) (PEA) obtained from renewable resources with citrate and itaconate cross-linkers and appropriate photopolymerization initiators, terminators, and dyes. The mechanical features and the relative biocompatibility of 3D-printed objects have been carefully studied to evaluate the possible resin implementation in the field of the textile fashion industry.9 pĂĄgina
Loco-regional treatment with temozolomide-loaded thermogels prevents glioblastoma recurrences in orthotopic human xenograft models
Glioblastoma multiforme (GBM) is the most aggressive primary tumor of the central nervous system and the diagnosis is often dismal. GBM pharmacological treatment is strongly limited by its intracranial location beyond the bloodâbrain barrier (BBB). While Temozolomide (TMZ) exhibits the best clinical performance, still less than 20% crosses the BBB, therefore requiring administration of very high doses with resulting unnecessary systemic side efects. Here, we aimed at designing new negative temperatureâresponsive gel formulations able to locally release TMZ beyond the BBB. The biocompatibility of a chitosanâÎČâglycerophosphateâbased thermogel (THG)âcontaining mesoporous
SiO2 nanoparticles (THG@SiO2) or polycaprolactone microparticles (THG@PCL) was ascertained in vitro and in vivo by cell counting and histological examination. Next, we loaded TMZ into such matrices (THG@SiO2âTMZ and THG@PCLâTMZ) and tested their therapeutic potential both in vitro and in vivo, in a glioblastoma resection and recurrence mouse model based on orthotopic growth of human cancer cells. The two newly designed anticancer formulations, consisting in TMZâsilica (SiO2@TMZ) dispersed in the thermogel matrix (THG@SiO2âTMZ) and TMZ, sprayâdried on PLC and incorporated into the thermogel (THG@PCLâTMZ), induced cell death in vitro. When applied intracranially to a resected U87âMGâRedâFLuc human GBM model, THG@SiO2âTMZ and THG@PCLâ
TMZ caused a signifcant reduction in the growth of tumor recurrences, when compared to untreated controls. THG@SiO2âTMZ and THG@PCLâTMZ are therefore new promising gelâbased local therapy candidates for the treatment of GBM
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esito esame 15-06-2018
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